Quantifying the entropic cost of cellular growth control

We quantify the amount of regulation required to control growth in living cells by a Maximum Entropy approach to the space of underlying metabolic states described by genome-scale models. Results obtained for E. coli and human cells are consistent with experiments and point to different regulatory strategies by which growth can be fostered or repressed. Moreover we explicitly connect the `inverse temperature' that controls MaxEnt distributions to the growth dynamics, showing that the initial size of a colony may be crucial in determining how an exponentially growing population organizes the phenotypic space.Comment: 3 page

Theory of controlled quantum dynamics

We introduce a general formalism, based on the stochastic formulation of quantum mechanics, to obtain localized quasi-classical wave packets as dynamically controlled systems, for arbitrary anharmonic potentials. The control is in general linear, and it amounts to introduce additional quadratic and linear time-dependent terms to the given potential. In this way one can construct for general systems either coherent packets moving with constant dispersion, or dynamically squeezed packets whose spreading remains bounded for all times. In the standard operatorial framework our scheme corresponds to a suitable generalization of the displacement and scaling operators that generate the coherent and squeezed states of the harmonic oscillator.Comment: LaTeX, A4wide, 28 pages, no figures. To appear in J. Phys. A: Math. Gen., April 199

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle

Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents (usually in the form of lactate) in the cell’s surroundings, a feature known as the Warburg effect. While the molecular basis of this phenomenon are still to be elucidated, it is clear that the spilling of energy resources contributes to creating a peculiar microenvironment for tumors, possibly characterized by a degree of toxicity. This suggests that mechanisms for recycling the fermentation products (e.g. a lactate shuttle) may be active, effectively inducing a mutually beneficial metabolic coupling between aberrant and non-aberrant cells. Here we analyze this scenario through a large-scale in silico metabolic model of interacting human cells. By going beyond the cell-autonomous description, we show that elementary physico- chemical constraints indeed favor the establishment of such a coupling under very broad conditions. The characterization we obtained by tuning the aberrant cell’s demand for ATP, amino-acids and fatty acids and/or the imbalance in nutrient partitioning provides quantitative support to the idea that synergistic multi-cell effects play a central role in cancer sustainmen

Decaying dark energy in light of the latest cosmological dataset

Decaying Dark Energy models modify the background evolution of the most common observables, such as the Hubble function, the luminosity distance and the Cosmic Microwave Background temperature-redshift scaling relation. We use the most recent observationally-determined datasets, including Supernovae Type Ia and Gamma Ray Bursts data, along with $H(z)$ and Cosmic Microwave Background temperature versus $z$ data and the reduced Cosmic Microwave Background parameters, to improve the previous constraints on these models. We perform a Monte Carlo Markov Chain analysis to constrain the parameter space, on the basis of two distinct methods. In view of the first method, the Hubble constant and the matter density are left to vary freely. In this case, our results are compatible with previous analyses associated with decaying Dark Energy models, as well as with the most recent description of the cosmological background. In view of the second method, we set the Hubble constant and the matter density to their best fit values obtained by the {\it Planck} satellite, reducing the parameter space to two dimensions, and improving the existent constraints on the model's parameters. Our results suggest that the accelerated expansion of the Universe is well described by the cosmological constant, and we argue that forthcoming observations will play a determinant role to constrain/rule out decaying Dark Energy.Comment: 15 pages, 3 figure, 2 table. Accepted in the Special Issue "Cosmological Inflation, Dark Matter and Dark Energy" on Symmetry Journa

Dynamics of multi-frequency minority games

The dynamics of minority games with agents trading on different time scales is studied via dynamical mean-field theory. We analyze the case where the agents' decision-making process is deterministic and its stochastic generalization with finite heterogeneous learning rates. In each case, we characterize the macroscopic properties of the steady states resulting from different frequency and learning rate distributions and calculate the corresponding phase diagrams. Finally, the different roles played by regular and occasional traders, as well as their impact on the system's global efficiency, are discussed.Comment: 9 pages, 5 figure